Understanding inherited neutropenias Maturation arrest of granulopoiesis in patients with severe congenital neutropenia In patients with severe congenital neutropenia, the maturation of granulocytic precursor cells arrests at the stage of promyelocytes and myelocytes, which accumulate in the bone marrow. The morphology of promyelocytes is also different: in patients with severe congenital neutropenia, promyelocytes have multiple … Continue reading Research areas